Agelasine D Suppresses RANKL-Induced Osteoclastogenesis via Down-Regulation of c-Fos, NFATc1 and NF-κB

Agelasine D Suppresses RANKL-Induced Osteoclastogenesis via Down-Regulation of c-Fos, NFATc1 and NF-κB

In the present study, we investigated the effect of agelasine D (AD) on osteoclastogenesis. Treatment of bone marrow macrophages (BMMs) with receptor activator of nuclear factor κB ligand (RANKL) resulted in a differentiation of BMMs into osteoclasts as evidenced by generation of tartrate-resistant...

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Bibliographic Details
Main Authors: Moo Rim Kang, Sun Ah Jo, Yeo Dae Yoon, Ki Hwan Park, Soo Jin Oh, Jieun Yun, Chang Woo Lee, Ki-Hoan Nam, Youngsoo Kim, Sang-Bae Han, Jiyeon Yu, Jaerang Rho, Jong Soon Kang
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Marine Drugs
Subjects:
agelasine D
osteoclastogenesis
c-Fos
NF-ATc1
NF-κB
Online Access:http://www.mdpi.com/1660-3397/12/11/5643

Internet

http://www.mdpi.com/1660-3397/12/11/5643

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