CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina

CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina

Background: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in micro...

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Bibliographic Details
Main Authors: Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
CYP2C19
Genetic polymorphism
Microvascular angina
Epoxyeicosatrienoic acid
Chronic inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906716300938

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http://www.sciencedirect.com/science/article/pii/S2352906716300938

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