Alternative lengthening of telomeres: remodeling the telomere architecture

Alternative lengthening of telomeres: remodeling the telomere architecture

To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies semi-conservative DNA replication. While the majority of human cancers do this by up-regulating telomerase enzyme activity, most of the remainde...

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Bibliographic Details
Main Authors: Dimitri eConomos, Hilda ePickett, Roger eReddel
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Oncology
Subjects:
Chromatin
Telomere
recombination
DNA damage response
Nuclear Receptors
Alternative lengthening of telomeres (ALT)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00027/full

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