Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy

Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy

Previous studies have suggested that cancer stem cells (CSCs) resisted radiotherapy and chemotherapy. P16INK4A is a biomarker for cervical carcinogenesis and reduces proliferation of stem cells. We aimed to investigate the expression and clinical significance of cyclin-dependent kinase inhibitor 2A...

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Bibliographic Details
Main Authors: Hung-Chun Fu, I-Chieh Chuang, Yi-Chien Yang, Pei-Chin Chuang, Hao Lin, Yu-Che Ou, Chan-Chao Chang Chien, Hui-Shan Huang, Hong-Yo Kang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
P16INK4A
SOX2
ALDH1A1
radioresistance
cervical cancer
cancer stem cells
Online Access:http://www.mdpi.com/1422-0067/19/9/2541

Internet

http://www.mdpi.com/1422-0067/19/9/2541

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