Epitope-Specific Serological Assays for RSV: Conformation Matters

Epitope-Specific Serological Assays for RSV: Conformation Matters

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fusion (pre-F) and post-fusion (post-F). Although 50%...

Full description

Bibliographic Details
Main Authors: Emily Phung, Lauren A. Chang, Kaitlyn M. Morabito, Masaru Kanekiyo, Man Chen, Deepika Nair, Azad Kumar, Grace L. Chen, Julie E. Ledgerwood, Barney S. Graham, Tracy J. Ruckwardt
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Vaccines
Subjects:
respiratory syncytial virus
monoclonal antibody competition
palivizumab competition assay
protein conformation
ELISA
immune correlates of protection
Online Access:https://www.mdpi.com/2076-393X/7/1/23

Internet

https://www.mdpi.com/2076-393X/7/1/23

Similar Items