Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric agonists alone has several disadvantages, limiting their usefulness as clinically relevant drugs....

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Bibliographic Details
Main Authors: Beatrice Polini, Chiara Cervetto, Sara Carpi, Simone Pelassa, Francesca Gado, Rebecca Ferrisi, Simone Bertini, Paola Nieri, Manuela Marcoli, Clementina Manera
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Life
Subjects:
endocannabinoids system
cannabinoid receptor type 2
cannabinoid receptor type 1
positive allosteric modulator
microglial cell
glutamate release
Online Access:https://www.mdpi.com/2075-1729/10/12/333

Internet

https://www.mdpi.com/2075-1729/10/12/333

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