Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric agonists alone has several disadvantages, limiting their usefulness as clinically relevant drugs....
Main Authors: | Beatrice Polini, Chiara Cervetto, Sara Carpi, Simone Pelassa, Francesca Gado, Rebecca Ferrisi, Simone Bertini, Paola Nieri, Manuela Marcoli, Clementina Manera |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
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Series: | Life |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-1729/10/12/333 |
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