Transcriptionally inactive hepatitis B virus episome DNA preferentially resides in the vicinity of chromosome 19 in 3D host genome upon infection

Transcriptionally inactive hepatitis B virus episome DNA preferentially resides in the vicinity of chromosome 19 in 3D host genome upon infection

Summary: The hepatitis B virus (HBV) infects 257 million people worldwide. HBV infection requires establishment and persistence of covalently closed circular (ccc) DNA, a viral episome, in nucleus. Here, we study cccDNA spatial localization in the 3D host genome by using chromosome conformation capt...

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Bibliographic Details
Main Authors: Dingbin Tang, Hanqing Zhao, Yumeng Wu, Bo Peng, Zhenchao Gao, Yinyan Sun, Jinzhi Duan, Yonghe Qi, Yunfei Li, Zhongmin Zhou, Guilan Guo, Yu Zhang, Cheng Li, Jianhua Sui, Wenhui Li
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
HBV
3D host genome
spatial localization
chromosome 19
episomal DNA
HBx protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006598

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http://www.sciencedirect.com/science/article/pii/S2211124721006598

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