Intracellular PD Modelling (<i>PD</i><sub>i</sub>) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

Increasing rifampicin (RIF) dosages could significantly reduce tuberculosis (TB) treatment durations. Understanding the pharmacokinetic-pharmacodynamics (PK&#8722;PD) of increasing RIF dosages could inform clinical regimen selection. We used intracellular PD modelling (<i>PD</i><s...

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Bibliographic Details
Main Authors: Ghaith Aljayyoussi, Samantha Donnellan, Stephen A. Ward, Giancarlo A. Biagini
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/11/6/278