Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-...

Full description

Bibliographic Details
Main Authors: Jonathan E. Schoenhals, Taylor R. Cushman, Hampartsoum B. Barsoumian, Ailin Li, Alexandra P. Cadena, Sharareh Niknam, Ahmed I. Younes, Mauricio da Silva Caetano, Maria Angelica Cortez, James W. Welsh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
PD1 resistance
radiotherapy
immunotherapy
GITR
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02170/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02170/full

Similar Items