Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein

Abstract Previous studies of the alpha-synuclein null mutant mice on the C57Bl6 genetic background have revealed reduced number of dopaminergic neurons in their substantia nigra pars compacta (SNpc). However, the presence in genomes of the studied mouse lines of additional genetic modifications that...

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Bibliographic Details
Main Authors: Valeria V. Goloborshcheva, Kirill D. Chaprov, Ekaterina V. Teterina, Ruslan Ovchinnikov, Vladimir L. Buchman
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Brain
Subjects:
Dopaminergic neurons
Substantia nigra
Striatum
Alpha-synuclein
Null mutant mice
Online Access:http://link.springer.com/article/10.1186/s13041-020-00613-5

Internet

http://link.springer.com/article/10.1186/s13041-020-00613-5

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