hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis

Abstract In periodontitis, gingival fibroblasts (GFs) interact with and respond to oral pathogens, significantly contributing to perpetuation of chronic inflammation and tissue destruction. The aim of this study was to determine the usefulness of the recently released hTERT-immortalized GF (TIGF) ce...

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Bibliographic Details
Main Authors: Katarzyna B. Lagosz-Cwik, Aleksandra Wielento, Weronika Lipska, Malgorzata Kantorowicz, Dagmara Darczuk, Tomasz Kaczmarzyk, Susan Gibbs, Jan Potempa, Aleksander M. Grabiec
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90037-5