Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice

The gut microbiota has been implicated in the therapeutic effects of antidiabetics. It is unclear if antidiabetics directly influences gut microbiome-host interaction. Oral peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, such as rosiglitazone, are potent insulin sensitizers used in t...

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Bibliographic Details
Main Authors: Mette Simone Aae Madsen, Rikke Veggerby Grønlund, John Eid, Mikkel Christensen-Dalsgaard, Morten Sommer, Kristoffer Rigbolt, Martin Rønn Madsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen, Martin Mikkelsen
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Peroxisome proliferator-activated receptor-γ
Diabetes
Mouse model
Gut microbiome
Gut transcriptome
Gut segment
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220311586

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http://www.sciencedirect.com/science/article/pii/S0753332220311586

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