Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

Characterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

Butyrylcholinesterase deficiency is characterized by prolonged apnea after the use of muscle relaxants (suxamethonium or mivacurium) in patients who have mutations in the BCHE gene. Here, we report a case of prolonged neuromuscular block after administration of suxamethonium leading to the discovery...

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Bibliographic Details
Main Authors: Herve Delacour, Sofya Lushchekina, Isabelle Mabboux, Aurore Bousquet, Franck Ceppa, Lawrence M Schopfer, Oksana Lockridge, Patrick Masson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4108472?pdf=render

Internet

http://europepmc.org/articles/PMC4108472?pdf=render

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