<i>Divide et impera</i>: An <i>In Silico</i> Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

<i>Divide et impera</i>: An <i>In Silico</i> Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavailability, toxicity, and emergence of resistant strai...

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Bibliographic Details
Main Authors: Hanieh Ghassabian, Federico Falchi, Martina Timmoneri, Beatrice Mercorelli, Arianna Loregian, Giorgio Palù, Gualtiero Alvisi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
HCMV
protein-protein interactions
small molecules
ppUL44
PAP
pUL54
Online Access:https://www.mdpi.com/1999-4915/13/5/941

Internet

https://www.mdpi.com/1999-4915/13/5/941

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