Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome

Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome

We previously reported that the highly reactive cell-free heme (CFH) is increased in the plasma of patients with chronic lung injury and causes pulmonary edema in animal model of acute respiratory distress syndrome (ARDS) post inhalation of halogen gas. However, the mechanisms by which CFH causes pu...

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Bibliographic Details
Main Authors: Saurabh Aggarwal, Ahmed Lazrak, Israr Ahmad, Zhihong Yu, Ayesha Bryant, James A. Mobley, David A. Ford, Sadis Matalon
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Cell-free heme
Halogenated lipids
Carbonylation
Hemopexin
Spectrin
Epithelial sodium channel
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720304894

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http://www.sciencedirect.com/science/article/pii/S2213231720304894

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