Multiplex precise base editing in cynomolgus monkeys

Multiplex precise base editing in cynomolgus monkeys

Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.

Bibliographic Details
Main Authors: Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng, Shihua Yang
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16173-0

Internet

https://doi.org/10.1038/s41467-020-16173-0

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