Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investigated effects of tadalafil and macitentan alone or...

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Bibliographic Details
Main Authors: Argen Mamazhakypov, Astrid Weiß, Sven Zukunft, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Christina Vroom, Aleksandar Petrovic, Djuro Kosanovic, Norbert Weissmann, Werner Seeger, Ingrid Fleming, Marc Iglarz, Friedrich Grimminger, Hossein A. Ghofrani, Soni S. Pullamsetti, Ralph T. Schermuly
Format: Article
Language:English
Published: SAGE Publishing 2020-11-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894020947283

Internet

https://doi.org/10.1177/2045894020947283

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