Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling

Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling

Epithelial-to-mesenchymal transition (EMT) is a key process that occurs during tumor metastasis, affecting a variety of malignancies including colorectal cancer (CRC). Exosomes mediate cell-cell communication by transporting cell-derived proteins and nucleic acids, including microRNAs (miRNAs). Exos...

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Bibliographic Details
Main Authors: Jian Bai, Xue Zhang, Dongdong Shi, Zhenxian Xiang, Shuyi Wang, Chaogang Yang, Qing Liu, Sihao Huang, Yan Fang, Weisong Zhang, Jialin Song, Bin Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
microRNA
EMT
extracellular vesicle
molecular signaling
gastrointestinal
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.568738/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.568738/full

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