CD73<sup>+</sup> CD127<sup>high</sup> Long-Term Memory CD4 T Cells are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection

CD73<sup>+</sup> CD127<sup>high</sup> Long-Term Memory CD4 T Cells are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection

HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall antigens. We report here that CD73 expression defines a subset of resting memory CD4+ T cells in peripheral blood, which highly express the α-chain of the IL-7 receptor (CD12...

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Bibliographic Details
Main Authors: Nabila Seddiki, John Zaunders, Chan Phetsouphanh, Vedran Brezar, Yin Xu, Helen M. McGuire, Michelle Bailey, Kristin McBride, Will Hey-Cunningham, Cynthia Mee Ling Munier, Laura Cook, Stephen Kent, Andrew Lloyd, Barbara Cameron, Barbara Fazekas de St Groth, Kersten Koelsch, Mark Danta, Hakim Hocini, Yves Levy, Anthony D. Kelleher
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
CD73
CD4+ subsets
HIV-1 viral reservoir
Online Access:https://www.mdpi.com/1422-0067/22/2/912

Internet

https://www.mdpi.com/1422-0067/22/2/912

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