Detecting T cell receptors involved in immune responses from single repertoire snapshots.

Detecting T cell receptors involved in immune responses from single repertoire snapshots.

Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant information from large high-throughput sequencing of TCR repertoires (RepSeq) data is limited, because little is known abo...

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Bibliographic Details
Main Authors: Mikhail V Pogorelyy, Anastasia A Minervina, Mikhail Shugay, Dmitriy M Chudakov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000314

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https://doi.org/10.1371/journal.pbio.3000314

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