Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis

Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis

Abstract Background Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm resulting from BCR–ABL-transformed hematopoietic stem cells. Previous research has implicated multifunctional proinflammatory cytokines in CML development. It has been reported that Sirtuin 1 (SIRT1) as we...

Full description

Bibliographic Details
Main Authors: Lei Wang, Mingming Wang, Hongju Dou, Wenjie Lin, Lifang Zou
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
CML
Inflammation
SIRT1
TLR4
NFκB
ROS
Online Access:http://link.springer.com/article/10.1186/s12935-020-1152-z

Internet

http://link.springer.com/article/10.1186/s12935-020-1152-z

Similar Items