Synthetic Flavanones Augment the Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Synthetic Flavanones Augment the Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as the most promising anticancer agent in the TNF superfamily because of its selective cytotoxicity against tumor cells versus normal primary cells. However, as more tumor cells are reported to be resistant to TRAIL-mediat...

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Bibliographic Details
Main Authors: Wojciech Krol, Zenon P. Czuba, Dagmara Jaworska, Tomasz Janeczko, Joanna Bronikowska, Ewelina Szliszka, Edyta Kostrzewa-Susłow
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Molecules
Subjects:
flavanones
6-hydroxyflavanone (6-HF)
6-propionoxyflavanone (6-PF)
TRAIL
apoptosis
death receptor
mitochondrial pathway
cancer cells
Online Access:http://www.mdpi.com/1420-3049/17/10/11693

Internet

http://www.mdpi.com/1420-3049/17/10/11693

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