The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.

We previously demonstrated that, in the early stages of tau processing in Alzheimer’s disease, the N-terminal part of the molecule undergoes a characteristic cascade of phosphorylation and progressive misfolding of the proteins resulting in a structural conformation detected by Alz-50. In this immun...

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Bibliographic Details
Main Authors: Paola eFlores-Rodríguez, Miguel Angel eOntiveros-Torres, María del Carmen eCárdenas-Aguayo, Juan Pedro eLuna-Arias, MARCO ANTONIO eMERAZ-RÍOS, Amparo eViramontes-Pintos, Charles eHarrington, Claude eM. Wischik, Benjamín eFlorán, Raúl eMena, José eLuna-Muñoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer Disease
Neurofibrillary Tangles
Neurotoxicity
tau protein
Tau oligomers
Truncation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00033/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00033/full

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