A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Summary: Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-grade serous ovarian cancers (HGSOCs), but these tumors may also arise from ovarian surface epithelial cells (OSECs). We profiled global landscapes of gene expression and active chromatin to c...

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Bibliographic Details
Main Authors: Kate Lawrenson, Marcos A.S. Fonseca, Annie Y. Liu, Felipe Segato Dezem, Janet M. Lee, Xianzhi Lin, Rosario I. Corona, Forough Abbasi, Kevin C. Vavra, Huy Q. Dinh, Navjot Kaur Gill, Ji-Heui Seo, Simon Coetzee, Yvonne G. Lin, Tanja Pejovic, Paulette Mhawech-Fauceglia, Amy C. Rowat, Ronny Drapkin, Beth Y. Karlan, Dennis J. Hazelett, Matthew L. Freedman, Simon A. Gayther, Houtan Noushmehr
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471931455X

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http://www.sciencedirect.com/science/article/pii/S221112471931455X

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