Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to decipher complex signaling mechanisms as they allow selective act...

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Bibliographic Details
Main Authors: Francesco De Pascali, Mohammed Akli Ayoub, Riccardo Benevelli, Silvia Sposini, Jordan Lehoux, Nathalie Gallay, Pauline Raynaud, Flavie Landomiel, Frédéric Jean-Alphonse, Christophe Gauthier, Lucie P. Pellissier, Pascale Crépieux, Anne Poupon, Asuka Inoue, Nicolas Joubert, Marie-Claude Viaud-Massuard, Livio Casarini, Manuela Simoni, Aylin C. Hanyaloglu, Selva G. Nataraja, Henry N. Yu, Stephen S. Palmer, Romain Yvinec, Eric Reiter
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
FSHR
biased signaling
allosteric ligands
system bias
operational model
Online Access:https://www.mdpi.com/1422-0067/22/18/9850

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https://www.mdpi.com/1422-0067/22/18/9850

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