Role of P2X7R in the development and progression of pulmonary hypertension

Role of P2X7R in the development and progression of pulmonary hypertension

Abstract Background Pulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes to PAH pathogenesis, but the role of the upstream molecular P2X7 recept...

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Bibliographic Details
Main Authors: Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan, Xiaolu Li
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
P2X7R
NLRP3
Macrophage
Online Access:http://link.springer.com/article/10.1186/s12931-017-0603-0

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http://link.springer.com/article/10.1186/s12931-017-0603-0

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