Bid regulates the pathogenesis of neurotropic reovirus.
Reovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-kappaB-driven transcription of proapoptotic cellular genes is required for the effector phase of the apoptotic response. Although both extrinsic death-receptor signaling pathways and intrinsi...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-07-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2895667?pdf=render |