Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast

Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast

Reduction of physiologic replication-independent endogenous DNA double strand breaks (Phy-RIND-EDSBs) in chronological aging yeast increases pathologic RIND-EDSBs (Path-RIND-EDSBs). Path-RIND-EDSBs can occur spontaneously in non-dividing cells without any inductive agents, and they must be repaired...

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Bibliographic Details
Main Authors: Monnat Pongpanich, Maturada Patchsung, Apiwat Mutirangura
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
replication-independent endogenous DNA double-strand breaks
repair defect
modified ends with insertion
Saccharomyces cerevisiae
chronological aging
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00501/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00501/full

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