Discovery of 4,6‐bis(2‐((E)‐benzylidene)hydrazinyl)pyrimidin‐2‐Amine with Antibiotic Activity

Discovery of 4,6‐bis(2‐((E)‐benzylidene)hydrazinyl)pyrimidin‐2‐Amine with Antibiotic Activity

Abstract Robenidine (E)‐N′‐((E)‐1‐(4‐chlorophenyl)ethylidene)‐2‐(1‐(4‐chlorophenyl)ethylidene)hydrazine‐1‐carboximidhydrazide displays methicillin‐resistant Staphyoccoccus aureus (MRSA) and vancomycin‐resistant Enterococci (VRE) MICs of 2 μg mL−1. Herein we describe the structure‐activity relationsh...

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Bibliographic Details
Main Authors: Dr. Cecilia C. Russell, Dr. Andrew Stevens, Kelly A. Young, Jennifer R. Baker, Siobhann N. McCluskey, Dr. Manouchehr Khazandi, Hongfei Pi, Dr. Abiodun Ogunniyi, Dr. Stephen W. Page, Prof. Darren J. Trott, Prof. Adam McCluskey
Format: Article
Language:English
Published: Wiley-VCH 2019-07-01
Series:ChemistryOpen
Subjects:
Aminopyrimidines
antibacterial activity
robenidine
drugs discovery
Online Access:https://doi.org/10.1002/open.201800241

Internet

https://doi.org/10.1002/open.201800241

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