Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.

Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons in the central nervous system. Although most cases of ALS are sporadic, about 5-10% of cases are familial (FALS) with approximately 20% of FALS caused by mutations in the Cu/Zn superoxide dismutase (...

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Bibliographic Details
Main Authors: Terry D Heiman-Patterson, Elizabeth P Blankenhorn, Roger B Sher, Juliann Jiang, Priscilla Welsh, Meredith C Dixon, Jeremy I Jeffrey, Philip Wong, Gregory A Cox, Guillermo M Alexander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4357475?pdf=render

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http://europepmc.org/articles/PMC4357475?pdf=render

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