PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions

PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions

ABSTRACT Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, the mechanism underlying the activation function of PCGF6 is poorly understood. Here...

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Bibliographic Details
Main Authors: Xiaona Huang, Chao Wei, Fenjie Li, Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, Junjun Ding
Format: Article
Language:English
Published: SpringerOpen 2019-04-01
Series:Protein & Cell
Subjects:
PCGF6
Polycomb group
super-enhancer
3D chromatin
pluripotency
Online Access:http://link.springer.com/article/10.1007/s13238-019-0629-9

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http://link.springer.com/article/10.1007/s13238-019-0629-9

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