Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition

Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition

K-Ras mutations are a hallmark of human pancreatic adenocarcinoma (PDAC) and epithelial-mesenchymal-transition (EMT) is a driver of progression. Oncogenic K-Ras causes the constitutive activation of NF-kB and the switch-on of an inflammatory program, which further fuels NF-kB and STAT3 activation. I...

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Bibliographic Details
Main Authors: Imran Siddiqui, Marco Erreni, Mohammad Azhar Kamal, Chiara Porta, Federica Marchesi, Samantha Pesce, Fabio Pasqualini, Silvia Schiarea, Chiara Chiabrando, Alberto Mantovani, Paola Allavena
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:OncoImmunology
Subjects:
cancer immunotherapy
emt
inflammation
oncogene
therapeutic antibodies
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1388485

Internet

http://dx.doi.org/10.1080/2162402X.2017.1388485

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