Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization
Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents. Its actions are mediated via its cognate G-protein-coupled receptor, RXFP1 although it also ‘pharmacologically’ activates RXFP2, the receptor for the...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-12-01
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Series: | Frontiers in Chemistry |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fchem.2013.00030/full |