Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Synthesis of fluorescent analogues of relaxin family peptides and their preliminary in vitro and in vivo characterization

Relaxin, a heterodimeric polypeptide hormone, is a key regulator of collagen metabolism and multiple vascular control pathways in humans and rodents. Its actions are mediated via its cognate G-protein-coupled receptor, RXFP1 although it also ‘pharmacologically’ activates RXFP2, the receptor for the...

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Bibliographic Details
Main Authors: Linda eChan, Craig eSmith, Berenice eChua, Feng eLin, Ross eBathgate, Frances eSeparovic, Andrew eGundlach, M. Akhter eHossain, John eWade
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Chemistry
Subjects:
Brain
Click Chemistry
Relaxin
RXFP1
RXFP2
Cy5.5 fluorophore
Online Access:http://journal.frontiersin.org/Journal/10.3389/fchem.2013.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fchem.2013.00030/full

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