Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

The accumulation of damaged mitochondria due to insufficient autophagy has been implicated in the pathophysiology of skeletal muscle aging. Ulk1 is an autophagy-related kinase that initiates autophagosome assembly and may also play a role in autophagosome degradation (i.e., autophagy flux), but the...

Full description

Bibliographic Details
Main Authors: Anna S. Nichenko, Jacob R. Sorensen, W. Michael Southern, Anita E. Qualls, Albino G. Schifino, Jennifer McFaline-Figueroa, Jamie E. Blum, Kayvan F. Tehrani, Hang Yin, Luke J. Mortensen, Anna E. Thalacker-Mercer, Sarah M. Greising, Jarrod A. Call
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
aging
mitophagy
autophagy flux
neuromuscular junction
sarcopenia
Online Access:https://www.mdpi.com/1422-0067/22/4/1937

Internet

https://www.mdpi.com/1422-0067/22/4/1937

Similar Items