Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

Abstract Background Previous studies have demonstrated that regulatory T cells (Tregs) play a protective role in the pathogenesis of chronic graft-versus-host disease (cGVHD). Tregs constitutively express the gene of the transcription factor Foxp3 whose CNS2 region is heavily methylated in conventio...

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Bibliographic Details
Main Authors: Gilles Fransolet, Grégory Ehx, Joan Somja, Loïc Delens, Muriel Hannon, Joséphine Muller, Sophie Dubois, Pierre Drion, Jo Caers, Stéphanie Humblet-Baron, Philippe Delvenne, Yves Beguin, Giuseppina Conteduca, Frédéric Baron
Format: Article
Language:English
Published: BMC 2016-07-01
Series:Journal of Hematology & Oncology
Subjects:
AZA
Azacytidine
Decitabine
DAC
Treg
Regulatory T cells
Online Access:http://link.springer.com/article/10.1186/s13045-016-0281-2

Internet

http://link.springer.com/article/10.1186/s13045-016-0281-2

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