The peripheral myeloid expansion driven by murine cancer progression is reversed by radiation therapy of the tumor.

The peripheral myeloid expansion driven by murine cancer progression is reversed by radiation therapy of the tumor.

Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen size. The frequency of myeloid cells does not dec...

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Bibliographic Details
Main Authors: Marka R Crittenden, Talicia Savage, Benjamin Cottam, Keith S Bahjat, William L Redmond, Shelly Bambina, Melissa Kasiewicz, Pippa Newell, Andrew M Jackson, Michael J Gough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3723876?pdf=render

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http://europepmc.org/articles/PMC3723876?pdf=render

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