Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs

Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs

Abstract In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (Total_score) and C log P of CPs are higher than that of catalpol, which show that t...

Full description

Bibliographic Details
Main Authors: Chunhong Dong, Shuanglin Liu, Xiaodong Cheng, Qiang Wang, Shiqing Jiang, Guoqing Wang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Chemistry
Subjects:
Molecular docking
Synthesis
Catalpol propionate
Antiaging drug
Online Access:http://link.springer.com/article/10.1186/s13065-019-0626-3

Internet

http://link.springer.com/article/10.1186/s13065-019-0626-3

Similar Items