Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Antibodies have generally long half-lives due to high...

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Bibliographic Details
Main Authors: Fabio Selis, Giuseppina Focà, Annamaria Sandomenico, Carla Marra, Concetta Di Mauro, Gloria Saccani Jotti, Silvia Scaramuzza, Annalisa Politano, Riccardo Sanna, Menotti Ruvo, Giancarlo Tonon
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
PEGylation
antibody fragment
Fab
papain digestion
pepsin digestion
pharmacokinetics
Online Access:http://www.mdpi.com/1422-0067/17/4/491

Internet

http://www.mdpi.com/1422-0067/17/4/491

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