A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment

A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment

Glioblastomas (GBM) are the common and aggressive primary brain tumors that are incurable by conventional therapies. Immunotherapy with immune checkpoint inhibitors is not effective in GBM patients due to the highly immunosuppressive tumor microenvironment (TME) restraining the infiltration and acti...

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Bibliographic Details
Main Authors: Paulina Pilanc, Kamil Wojnicki, Adria-Jaume Roura, Salwador Cyranowski, Aleksandra Ellert-Miklaszewska, Natalia Ochocka, Bartłomiej Gielniewski, Marcin M. Grzybowski, Roman Błaszczyk, Paulina S. Stańczak, Paweł Dobrzański, Bozena Kaminska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
arginase inhibitor
tumor microenvironment
glioma associated microglia and macrophages
immune checkpoint inhibitor
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.703465/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.703465/full

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