ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding[S]

ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding[S]

ATP-binding cassette protein A1 (ABCA1) plays a major role in cholesterol homeostasis and high-density lipoprotein (HDL) metabolism. Although it is predicted that apolipoprotein A-I (apoA-I) directly binds to ABCA1, the physiological importance of this interaction is still controversial and the conf...

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Bibliographic Details
Main Authors: Kohjiro Nagao, Kei Takahashi, Yuya Azuma, Mie Takada, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette protein A1
apolipoproteins
cholesterol efflux
HDL
transport
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408065

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520408065

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