Distinguishing linear and branched evolution given single-cell DNA sequencing data of tumors

Distinguishing linear and branched evolution given single-cell DNA sequencing data of tumors

Abstract Background Cancer arises from an evolutionary process where somatic mutations give rise to clonal expansions. Reconstructing this evolutionary process is useful for treatment decision-making as well as understanding evolutionary patterns across patients and cancer types. In particular, clas...

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Bibliographic Details
Main Authors: Leah L. Weber, Mohammed El-Kebir
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Algorithms for Molecular Biology
Subjects:
Intra-tumor heterogeneity
Perfect phylogeny
Constraint programming
Single-cell DNA sequencing
Online Access:https://doi.org/10.1186/s13015-021-00194-5

Internet

https://doi.org/10.1186/s13015-021-00194-5

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