rAAV2-Retro Enables Extensive and High-Efficient Transduction of Lower Motor Neurons following Intramuscular Injection

rAAV2-Retro Enables Extensive and High-Efficient Transduction of Lower Motor Neurons following Intramuscular Injection

The motor system controls muscle movement through lower motor neurons in the spinal cord and brainstem. Lower motor neurons are efferent neurons in the central nervous system (CNS) characterized by axonal projections that reach specific targets in the periphery. Lower motor neuron lesions result in...

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Bibliographic Details
Main Authors: Zhilong Chen, Guoqing Fan, Anan Li, Jing Yuan, Tonghui Xu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
intramuscular injection
motor neurons
gene therapy
cerebrospinal fluid
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301317

Internet

http://www.sciencedirect.com/science/article/pii/S2329050119301317

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