Forsythiasides-Rich Extract From Forsythiae Fructus Inhibits Mast Cell Degranulation by Enhancing Mitochondrial Ca2+ Uptake

Forsythiasides-Rich Extract From Forsythiae Fructus Inhibits Mast Cell Degranulation by Enhancing Mitochondrial Ca2+ Uptake

Mast cells (MCs) activated via IgE/FcεRI or MAS-related G protein coupled receptor (Mrgpr)-mediated pathway can release granules that play prominent roles in hypersensitivity reactions. Forsythiae Fructus, a well-known traditional Chinese medicine, has been clinically used for allergic diseases. Alt...

Full description

Bibliographic Details
Main Authors: Ruijuan Qi, Yuan Kang, Ximeng Li, Xiaoyu Zhang, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
forsythiae fructus
mast cell degranulation
IgE
Mrgpr
cytosolic Ca2+
mitochondrial Ca2+
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696729/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696729/full

Similar Items