Increased Regenerative Capacity of the Olfactory Epithelium in Niemann–Pick Disease Type C1

Increased Regenerative Capacity of the Olfactory Epithelium in Niemann–Pick Disease Type C1

Niemann–Pick disease type C1 (NPC1) is a fatal neurovisceral lysosomal lipid storage disorder. The mutation of the NPC1 protein affects the homeostasis and transport of cholesterol and glycosphingolipids from late endosomes/lysosomes to the endoplasmic reticulum resulting in progressive neurodegener...

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Bibliographic Details
Main Authors: Anja Meyer, Andreas Wree, René Günther, Carsten Holzmann, Oliver Schmitt, Arndt Rolfs, Martin Witt
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:International Journal of Molecular Sciences
Subjects:
immunohistochemistry
cyclodextrin
allopregnanolone
miglustat
NPC1
mouse model
olfactory mucosa
bromodeoxyuridine
olfactory marker protein
Online Access:http://www.mdpi.com/1422-0067/18/4/777

Internet

http://www.mdpi.com/1422-0067/18/4/777

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