Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44)

Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44)

Abstract Background Children with constitutional trisomy 21, i.e. Down syndrome (DS, OMIM #190685) have a 10 to 20-fold increased risk for a hematopoietic malignancy. They may suffer from acute lymphoblastic leukemia or acute myeloid leukemia (AML). AML referred to as myeloid leukemia of Down syndro...

Full description

Bibliographic Details
Main Authors: Faten Moassass, Abdulsamad Wafa, Thomas Liehr, Ayman Al-Ablog, Walid AL Achkar
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Molecular Cytogenetics
Subjects:
Down syndrome
Trisomy 21
AML
Acquired chromosomal abnormalities (ACAs)
Clone evolution
Cytogenetics
Online Access:http://link.springer.com/article/10.1186/s13039-018-0370-8

Internet

http://link.springer.com/article/10.1186/s13039-018-0370-8

Similar Items