In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against <i>Leishmania donovani</i> and <i>Trypanosoma brucei</i>

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against <i>Leishmania donovani</i> and <i>Trypanosoma brucei</i>

Kinetoplastid parasites, including <i>Leishmania</i> and <i>Trypanosoma</i> spp., are life threatening pathogens with a worldwide distribution. Next-generation therapeutics for treatment are needed as current treatments have limitations, such as toxicity and drug resistance....

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Bibliographic Details
Main Authors: Trong-Nhat Phan, Kyung-Hwa Baek, Nakyung Lee, Soo Young Byun, David Shum, Joo Hwan No
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
<i>Leishmania</i>
<i>Trypanosoma</i>
mammalian target of rapamycin
phosphoinositide 3-kinase
inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/8/1980

Internet

https://www.mdpi.com/1420-3049/25/8/1980

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