Expanding the Scope of Non-invasive Prenatal Testing to Detect Fetal Chromosomal Copy Number Variations

Expanding the Scope of Non-invasive Prenatal Testing to Detect Fetal Chromosomal Copy Number Variations

Non-invasive prenatal testing (NIPT) for common fetal trisomies is effective. However, the usefulness of cell-free DNA testing to detect other chromosomal abnormalities is poorly understood. We analyzed the positive rate at different read depths in next-generation sequencing (NGS) and identified a s...

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Bibliographic Details
Main Authors: Songchang Chen, Lanlan Zhang, Jiong Gao, Shuyuan Li, Chunxin Chang, Yiyao Chen, Hongjun Fei, Junyu Zhang, Yanlin Wang, Hefeng Huang, Chenming Xu, Daru Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
non-invasive prenatal testing
copy number variation
sequencing depth
microdeletion/microduplication syndromes
next generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.649169/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.649169/full

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