microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

Abstract Background Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the N-terminal of TBP is the causal mutation in SCA17. Brain sections o...

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Bibliographic Details
Main Authors: Reema Roshan, Ashwani Choudhary, Aksheev Bhambri, Bhawani Bakshi, Tanay Ghosh, Beena Pillai
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Neuroinflammation
Subjects:
Polyglutamine diseases
SCA17
IFN-ϒ
STAT1
Online Access:http://link.springer.com/article/10.1186/s12974-017-0925-3

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http://link.springer.com/article/10.1186/s12974-017-0925-3

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