Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART ha...

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Bibliographic Details
Main Authors: Sophie Reuse, Miriam Calao, Kabamba Kabeya, Allan Guiguen, Jean-Stéphane Gatot, Vincent Quivy, Caroline Vanhulle, Aurélia Lamine, Dolores Vaira, Dominique Demonte, Valérie Martinelli, Emmanuelle Veithen, Thomas Cherrier, Véronique Avettand, Solène Poutrel, Jacques Piette, Yvan de Launoit, Michel Moutschen, Arsène Burny, Christine Rouzioux, Stéphane De Wit, Georges Herbein, Olivier Rohr, Yves Collette, Olivier Lambotte, Nathan Clumeck, Carine Van Lint
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2699633?pdf=render

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http://europepmc.org/articles/PMC2699633?pdf=render

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